The Anti-Grp75 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GRP75, HSPA9, Mortalin, mot, and MTHSP75. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-Grp75 antibody has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Stress-70 protein, mitochondrial(HSPA9) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: HSPA9(heat shock 70kDa protein 9(mortalin)), also known as GRP75, mot-2, mthsp75, PBP74,HSPA9B, MORTALIN or MORTALIN, PERINUCLEAR, is a highly conserved member of the HSP70 family of proteins. It functions as a chaperone in the mitochondria, cytoplasm, and centrosome. The HSPA9 gene is mapped to chromosome 5q31.2 based on an alignment of the HSPA9 sequence with the genomic sequence. Knockdown of HSPA9 in erythroid cultures was associated with an increased number of cells in the G0/G1 phase of the cell cycle and accelerated apoptosis. Knockdown of Hspa9 in mouse bone marrow cells, followed by transplantation into wildtype recipients, also resulted in loss of erythroid cell number. Haploinsufficiency for HSPA9 may contribute to abnormal hematopoiesis in myelodysplastic syndromes with deletions spanning chromosome 5q31.2. This protein plays a role in the control of cell proliferation. It may also act as a chaperone